How Long to Cook a Salmon Fillet at 350 Degrees
It will take approximately 22 minutes to bake a standard-size salmon fillet at 350 degrees Fahrenheit. You can shorten this cooking time by covering the salmon or wrapping it in foil, which allows it to steam in its own juices. You can check for doneness by poking at the fish with a fork at its thickest point; if it flakes easily, it's cooked. You can also use a thermometer to check the core temperature. Once it has reached 145 degrees, the salmon is safe to eat.
While some prefer to cook salmon fillets in a 350-degree oven, others prefer a slightly higher oven temperature. We know that every oven is different, so try both 350 degrees and 375 degrees to find the right oven temp for your perfectly baked salmon fillet. A classic baked salmon fillet recipe is a quick and simple dish that can be enjoyed any night of the week.