How Long to Cook Chicken Breast at 375 Degrees
If you're cooking boneless, skinless chicken breasts in an oven set to 375 degrees Fahrenheit, you'll get the best results if you let them cook for 20 to 30 minutes. If you're cooking large bone-in and skin-on chicken breasts, leave them in the oven for 35 to 40 minutes. No matter what type of chicken breast you cook, be sure to let it rest for ten minutes before slicing into it, as this allows the juices to redistribute and lets the carryover heat finish the cooking process.
If you aren't sure whether or not to take your chicken breasts out of the oven, use a meat thermometer. Stick the probe into the thickest part of the largest piece of chicken: When the temperature on the thermometer registers 165 degrees Fahrenheit, it's fully cooked and safe to eat.
It's worth noting that if you increase the oven temperature to 400 degrees, you can lessen the cook time by a little bit. The chicken breast still comes out perfectly cooked.